Assay Detail
Binding
CHEMBL872346
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Inhibitory concentration against Mineralocorticoid receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.42 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410683 | GUGGULSTERONE | — | 1 | 7.43 |
| CHEMBL402063 | E-GUGGULSTERONE | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410683 | GUGGULSTERONE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL402063 | E-GUGGULSTERONE | Ki | = | 39.0 | nM | 7.41 |