Assay Detail
Binding
CHEMBL872349
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Inhibitory constant against Dipeptidylpeptidase IV activity
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.73 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280658 | — | — | 1 | 7.55 |
| CHEMBL22511 | — | — | 1 | 7.25 |
| CHEMBL196545 | — | — | 1 | 7.09 |
| CHEMBL366250 | — | — | 1 | 6.96 |
| CHEMBL365560 | — | — | 1 | 6.93 |
| CHEMBL278393 | — | — | 1 | 6.92 |
| CHEMBL23981 | — | — | 1 | 6.89 |
| CHEMBL382531 | — | — | 1 | 6.30 |
| CHEMBL372115 | — | — | 1 | 5.90 |
| CHEMBL194258 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280658 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL22511 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL196545 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL366250 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL365560 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL278393 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL23981 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL382531 | — | Ki | = | 504.0 | nM | 6.30 |
| CHEMBL372115 | — | Ki | = | 1267.0 | nM | 5.90 |
| CHEMBL194258 | — | Ki | = | 3350.0 | nM | 5.47 |