Assay Detail
Binding
CHEMBL872388
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards cloned human 5-HT2C receptor using [3H]5-carboximidotryptamine as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of potent and selective serotonin 5-HT1B receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.20 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197408 | — | — | 1 | 8.19 |
| CHEMBL15928 | GR-127935 | — | 1 | 6.98 |
| CHEMBL372453 | — | — | 1 | 6.57 |
| CHEMBL196169 | — | — | 1 | 5.97 |
| CHEMBL197796 | — | — | 1 | 5.94 |
| CHEMBL370128 | — | — | 1 | 5.91 |
| CHEMBL196370 | — | — | 1 | 5.71 |
| CHEMBL196598 | — | — | 1 | 5.55 |
| CHEMBL195927 | — | — | 1 | 5.00 |
| CHEMBL194206 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197408 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL15928 | GR-127935 | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL372453 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL196169 | — | Ki | = | 1077.0 | nM | 5.97 |
| CHEMBL197796 | — | Ki | = | 1145.0 | nM | 5.94 |
| CHEMBL370128 | — | Ki | = | 1241.0 | nM | 5.91 |
| CHEMBL196370 | — | Ki | = | 1937.0 | nM | 5.71 |
| CHEMBL196598 | — | Ki | = | 2833.0 | nM | 5.55 |
| CHEMBL195927 | — | Ki | = | 9954.0 | nM | 5.00 |
| CHEMBL194206 | — | Ki | > | 10000.0 | nM | - |