Assay Detail
Binding
CHEMBL872391
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Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.60 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196744 | — | — | 1 | 6.04 |
| CHEMBL197195 | — | — | 1 | 6.04 |
| CHEMBL197162 | — | — | 1 | 5.89 |
| CHEMBL195247 | — | — | 1 | 5.75 |
| CHEMBL194727 | — | — | 1 | 5.57 |
| CHEMBL194755 | — | — | 1 | 5.46 |
| CHEMBL197214 | — | — | 1 | 5.39 |
| CHEMBL198993 | — | — | 1 | 5.20 |
| CHEMBL59725 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196744 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL197195 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL197162 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL195247 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL194727 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL194755 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL197214 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL198993 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL59725 | — | Ki | = | 8800.0 | nM | 5.06 |