Assay Detail
Binding
CHEMBL872394
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory constant against [3H]spiperone binding to human dopamine D2 receptor expressed in CHO cells
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-[omega-(1H-indol-3-yl)alkyl]piperazines, novel potential antipsychotics combining potent dopamine D2 receptor antagonism with potent serotonin reuptake inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.98 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198224 | — | — | 1 | 9.00 |
| CHEMBL198357 | — | — | 1 | 9.00 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.70 |
| CHEMBL194240 | — | — | 1 | 8.68 |
| CHEMBL198069 | — | — | 1 | 8.37 |
| CHEMBL198070 | — | — | 1 | 8.35 |
| CHEMBL370457 | — | — | 1 | 8.33 |
| CHEMBL194844 | — | — | 1 | 8.29 |
| CHEMBL196172 | — | — | 1 | 8.28 |
| CHEMBL196514 | — | — | 1 | 8.16 |
| CHEMBL199045 | — | — | 1 | 8.13 |
| CHEMBL193854 | — | — | 1 | 8.09 |
| CHEMBL198216 | — | — | 1 | 8.06 |
| CHEMBL263329 | — | — | 1 | 8.04 |
| CHEMBL196893 | — | — | 1 | 7.97 |
| CHEMBL198107 | — | — | 1 | 7.97 |
| CHEMBL198040 | — | — | 1 | 7.95 |
| CHEMBL383396 | — | — | 1 | 7.94 |
| CHEMBL369984 | — | — | 1 | 7.84 |
| CHEMBL196132 | — | — | 1 | 7.82 |
| CHEMBL197839 | — | — | 1 | 7.82 |
| CHEMBL194510 | — | — | 1 | 7.81 |
| CHEMBL372735 | — | — | 1 | 7.80 |
| CHEMBL197665 | — | — | 1 | 7.75 |
| CHEMBL193501 | — | — | 1 | 7.72 |
| CHEMBL198812 | — | — | 1 | 7.69 |
| CHEMBL196171 | — | — | 1 | 7.68 |
| CHEMBL365605 | — | — | 1 | 7.62 |
| CHEMBL370359 | — | — | 1 | 7.50 |
| CHEMBL197943 | — | — | 1 | 7.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198224 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL198357 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL194240 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL198069 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL198070 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL370457 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL194844 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL196172 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL196514 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL199045 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL193854 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL198216 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL263329 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL198107 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL196893 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL198040 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL383396 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL369984 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL196132 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL197839 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL194510 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL372735 | — | Ki | = | 15.9 | nM | 7.80 |
| CHEMBL197665 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL193501 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL198812 | — | Ki | = | 20.3 | nM | 7.69 |
| CHEMBL196171 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL365605 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL370359 | — | Ki | = | 31.6 | nM | 7.50 |
| CHEMBL197943 | — | Ki | = | 35.7 | nM | 7.45 |
| CHEMBL196505 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL195015 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL198041 | — | Ki | = | 90.0 | nM | 7.05 |