Assay Detail
Binding
CHEMBL872498
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of [125I]RTI-55 binding to dopamine transporter in HEK cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bivalent biogenic amine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.72 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306208 | — | — | 1 | 8.96 |
| CHEMBL307314 | — | — | 1 | 8.17 |
| CHEMBL432727 | — | — | 1 | 7.74 |
| CHEMBL407803 | — | — | 1 | 7.66 |
| CHEMBL303266 | — | — | 1 | 7.19 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306208 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL307314 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL432727 | — | Ki | = | 18.4 | nM | 7.74 |
| CHEMBL407803 | — | Ki | = | 21.7 | nM | 7.66 |
| CHEMBL303266 | — | Ki | = | 65.1 | nM | 7.19 |
| CHEMBL370805 | COCAINE | Ki | = | 272.0 | nM | 6.57 |