Assay Detail
Binding
CHEMBL872510
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Ability to inhibit autophosphorylation of KinA/Sp0F assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus subtilis |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
KinA/Spo0F (sporulation kinase A/sporulation initiation phosphotransferase F) (CHEMBL2111331) ↗| Type | PROTEIN FAMILY |
| Organism | Bacillus subtilis (strain 168) |
Publication
SAR studies of diaryltriazoles against bacterial two-component regulatory systems and their antibacterial activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.37 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57037 | — | — | 1 | 5.10 |
| CHEMBL58536 | — | — | 1 | 4.80 |
| CHEMBL58439 | — | — | 1 | 4.62 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | 4.0 | 1 | 4.43 |
| CHEMBL58560 | — | — | 1 | 4.36 |
| CHEMBL441791 | — | — | 1 | 4.17 |
| CHEMBL60977 | — | — | 1 | 4.10 |
| CHEMBL60976 | — | — | 1 | 4.06 |
| CHEMBL301880 | — | — | 1 | 4.04 |
| CHEMBL300324 | — | — | 1 | 4.00 |
| CHEMBL292823 | — | — | 1 | - |
| CHEMBL61254 | — | — | 1 | - |
| CHEMBL58201 | — | — | 1 | - |
| CHEMBL58045 | — | — | 1 | - |
| CHEMBL301277 | — | — | 1 | - |
| CHEMBL58319 | — | — | 1 | - |
| CHEMBL58329 | — | — | 1 | - |
| CHEMBL291781 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57037 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL58536 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL58439 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL58560 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL441791 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL60977 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL60976 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL301880 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL300324 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL292823 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL61254 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL58201 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL58045 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL301277 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL58319 | — | IC50 | = | 380000.0 | nM | - |
| CHEMBL58329 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL291781 | — | IC50 | > | 500000.0 | nM | - |