Assay Detail
Functional
CHEMBL872614
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit 50% of murine leukemia L1210 cell growth was measured(in vitro) using MTT assay.
23
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Nucleosides and nucleotides. 175. Structural requirements of the sugar moiety for the antitumor activities of new nucleoside antimetabolites, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and -uracil1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.88 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318896 | — | — | 2 | 7.80 |
| CHEMBL317514 | — | — | 2 | 6.89 |
| CHEMBL100984 | — | — | 1 | 4.61 |
| CHEMBL99078 | — | — | 1 | 4.22 |
| CHEMBL99598 | — | — | 1 | - |
| CHEMBL610341 | — | — | 1 | - |
| CHEMBL98247 | — | — | 1 | - |
| CHEMBL316710 | — | — | 1 | - |
| CHEMBL442385 | — | — | 1 | - |
| CHEMBL330396 | — | — | 1 | - |
| CHEMBL99926 | — | — | 1 | - |
| CHEMBL99358 | — | — | 1 | - |
| CHEMBL316586 | — | — | 1 | - |
| CHEMBL99131 | — | — | 1 | - |
| CHEMBL319750 | — | — | 1 | - |
| CHEMBL101699 | — | — | 1 | - |
| CHEMBL330648 | — | — | 1 | - |
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | — | 1 | - |
| CHEMBL99557 | — | — | 1 | - |
| CHEMBL316513 | — | — | 1 | - |
| CHEMBL100158 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318896 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL317514 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL100984 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL99078 | — | IC50 | = | 60800.0 | nM | 4.22 |
| CHEMBL99598 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL610341 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL318896 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL98247 | — | IC50 | = | 354000.0 | nM | - |
| CHEMBL316710 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL442385 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL330396 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL99926 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL99358 | — | IC50 | = | 269000.0 | nM | - |
| CHEMBL100158 | — | IC50 | = | 148000.0 | nM | - |
| CHEMBL316586 | — | IC50 | = | 129000.0 | nM | - |
| CHEMBL319750 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL317514 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL101699 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL330648 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | IC50 | > | 350000.0 | nM | - |
| CHEMBL99557 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL316513 | — | IC50 | = | 338000.0 | nM | - |
| CHEMBL99131 | — | IC50 | > | 350000.0 | nM | - |