Assay Detail
Functional
CHEMBL872629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat non neuronal cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | neuronal |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Metabotropic glutamate receptor 8 (CHEMBL2718) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.95 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140197 | — | — | 1 | 8.00 |
| CHEMBL143210 | — | — | 1 | 7.51 |
| CHEMBL33567 | — | — | 1 | 7.22 |
| CHEMBL277475 | — | — | 1 | 6.68 |
| CHEMBL280563 | — | — | 1 | 6.40 |
| CHEMBL334160 | — | — | 1 | 5.88 |
| CHEMBL357043 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140197 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL143210 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL33567 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL277475 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL280563 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL334160 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL357043 | — | EC50 | > | 100000.0 | nM | - |