Assay Detail
Binding
CHEMBL872675
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In vitro binding affinity at opioid receptor kappa 1 was determined in human CHO cells using [3H]U-69593
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.69 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606986 | — | — | 1 | 10.10 |
| CHEMBL606925 | — | — | 1 | 9.96 |
| CHEMBL606985 | — | — | 1 | 9.43 |
| CHEMBL514774 | — | — | 1 | 9.39 |
| CHEMBL606924 | — | — | 1 | 9.31 |
| CHEMBL606987 | — | — | 1 | 9.22 |
| CHEMBL606923 | — | — | 1 | 8.85 |
| CHEMBL606876 | — | — | 1 | 7.21 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.95 |
| CHEMBL326684 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606986 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL606925 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL606985 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL514774 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL606924 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL606987 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL606923 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL606876 | — | Ki | = | 61.4 | nM | 7.21 |
| CHEMBL70 | MORPHINE | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL326684 | — | Ki | = | 304.0 | nM | 6.52 |