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Assay Detail

CHEMBL872685

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxic effect against human colon carcinoma cell line (HT-29)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Expert

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases.
Braña MF, Cacho M, García ML, Mayoral EP, López B, de Pascual-Teresa B, Ramos A, Acero N, Llinares F, Muñoz-Mingarro D, Lozach O, Meijer L.
J Med Chem (2005) 48 : 6843 -6854
PubMed 16250643 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 4.57 5.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL194734 1 5.07
CHEMBL196750 1 4.98
CHEMBL196083 1 4.14
CHEMBL408634 1 4.09
CHEMBL197894 1 -
CHEMBL198871 1 -
CHEMBL194795 1 -
CHEMBL195719 1 -
CHEMBL370302 1 -
CHEMBL197419 1 -
CHEMBL197512 1 -
CHEMBL196892 1 -
CHEMBL199126 1 -
CHEMBL199208 1 -
CHEMBL196470 1 -
CHEMBL370970 1 -
CHEMBL198058 1 -
CHEMBL197934 1 -
CHEMBL372190 1 -
CHEMBL438074 1 -
CHEMBL198658 1 -
CHEMBL426827 1 -
CHEMBL263961 1 -
CHEMBL260135 1 -
CHEMBL197902 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL194734 IC50 = 8500.0 nM 5.07
CHEMBL196750 IC50 = 10520.0 nM 4.98
CHEMBL196083 IC50 = 73000.0 nM 4.14
CHEMBL408634 IC50 = 80800.0 nM 4.09
CHEMBL197894 IC50 > 100000.0 nM -
CHEMBL198871 IC50 > 100000.0 nM -
CHEMBL194795 IC50 > 100000.0 nM -
CHEMBL195719 IC50 > 100000.0 nM -
CHEMBL370302 IC50 > 100000.0 nM -
CHEMBL197419 IC50 > 100000.0 nM -
CHEMBL197512 IC50 > 100000.0 nM -
CHEMBL196892 IC50 > 100000.0 nM -
CHEMBL199126 IC50 > 100000.0 nM -
CHEMBL199208 IC50 > 100000.0 nM -
CHEMBL196470 IC50 > 100000.0 nM -
CHEMBL370970 IC50 > 100000.0 nM -
CHEMBL198058 IC50 > 100000.0 nM -
CHEMBL197934 IC50 - nM -
CHEMBL372190 IC50 > 100000.0 nM -
CHEMBL438074 IC50 > 100000.0 nM -
CHEMBL198658 IC50 > 100000.0 nM -
CHEMBL426827 IC50 > 100000.0 nM -
CHEMBL263961 IC50 > 100000.0 nM -
CHEMBL260135 IC50 > 100000.0 nM -
CHEMBL197902 IC50 > 100000.0 nM -