Assay Detail
Binding
CHEMBL872688
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Inhibition of matrix metalloprotease-2 (MMP-2)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.11 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 8.15 |
| CHEMBL358539 | — | — | 1 | 7.80 |
| CHEMBL147882 | — | — | 1 | 7.75 |
| CHEMBL147881 | — | — | 1 | 7.62 |
| CHEMBL148214 | — | — | 1 | 7.58 |
| CHEMBL148171 | — | — | 1 | 7.57 |
| CHEMBL146718 | — | — | 1 | 7.48 |
| CHEMBL147489 | — | — | 1 | 7.12 |
| CHEMBL148406 | — | — | 1 | 6.82 |
| CHEMBL146289 | — | — | 1 | 6.37 |
| CHEMBL356124 | — | — | 1 | 6.14 |
| CHEMBL424130 | — | — | 1 | 6.07 |
| CHEMBL147604 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL358539 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL147882 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL147881 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL148214 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL148171 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL146718 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL147489 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL148406 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL146289 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL356124 | — | IC50 | = | 724.0 | nM | 6.14 |
| CHEMBL424130 | — | IC50 | = | 853.0 | nM | 6.07 |
| CHEMBL147604 | — | IC50 | = | 1099.0 | nM | 5.96 |