Assay Detail
Binding
CHEMBL872711
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Inhibitory activity of compound against Tissue Kallikrein (TK)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of potent and selective inhibitors of human plasma kallikrein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.75 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1160807 | — | — | 1 | 5.16 |
| CHEMBL1160813 | — | — | 1 | 4.33 |
| CHEMBL1160803 | — | — | 1 | - |
| CHEMBL1160805 | — | — | 1 | - |
| CHEMBL1160804 | — | — | 1 | - |
| CHEMBL1160809 | — | — | 1 | - |
| CHEMBL1160808 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1160807 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL1160813 | — | Ki | = | 47300.0 | nM | 4.33 |
| CHEMBL1160803 | — | Ki | > | 150000.0 | nM | - |
| CHEMBL1160805 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1160804 | — | Ki | > | 2500000.0 | nM | - |
| CHEMBL1160809 | — | Ki | = | 191000.0 | nM | - |
| CHEMBL1160808 | — | Ki | = | 223000.0 | nM | - |