Assay Detail
Functional
CHEMBL872717
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Apparent binding affinity against estradiol-stimulated T-47D cell proliferation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-47D |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
(S)-(+)-4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl]-2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.97 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68055 | ACOLBIFENE | 3.0 | 1 | 10.82 |
| CHEMBL308234 | — | — | 1 | 10.80 |
| CHEMBL291808 | — | — | 1 | 10.55 |
| CHEMBL67783 | — | — | 1 | 9.28 |
| CHEMBL441622 | — | — | 1 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68055 | ACOLBIFENE | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL308234 | — | Ki | = | 0.016 | nM | 10.80 |
| CHEMBL291808 | — | Ki | = | 0.028 | nM | 10.55 |
| CHEMBL67783 | — | Ki | = | 0.525 | nM | 9.28 |
| CHEMBL441622 | — | Ki | = | 4.22 | nM | 8.38 |