Assay Detail
Functional
CHEMBL872730
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Antagonist activity against rat 1A/2C subtype of N-methyl-D-aspartate (NMDA) receptor was determined by electrical assay in xenopus oocytes.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship for a series of 2-substituted 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles: potent subtype-selective inhibitors of N-methyl-D-aspartate (NMDA) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.18 | 4.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40465 | — | — | 1 | 4.19 |
| CHEMBL44301 | — | — | 1 | 4.17 |
| CHEMBL44412 | — | — | 1 | - |
| CHEMBL43928 | — | — | 1 | - |
| CHEMBL41073 | — | — | 1 | - |
| CHEMBL42274 | — | — | 1 | - |
| CHEMBL40454 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40465 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL44301 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL44412 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL43928 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL41073 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL42274 | — | IC50 | = | 132000.0 | nM | - |
| CHEMBL40454 | — | IC50 | = | 150000.0 | nM | - |