Assay Detail
Functional
CHEMBL872736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-tumor activity against human OVCAR-3 ovarian cancer cell lines by using MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Amino-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones. Synthesis, antitumor activity, and quantitative structure--activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.86 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.24 |
| CHEMBL145869 | — | — | 1 | 7.92 |
| CHEMBL174780 | — | — | 1 | 7.92 |
| CHEMBL145826 | — | — | 1 | 7.89 |
| CHEMBL147597 | — | — | 1 | 7.85 |
| CHEMBL146101 | — | — | 1 | 7.70 |
| CHEMBL173888 | — | — | 1 | 7.70 |
| CHEMBL179290 | — | — | 1 | 7.48 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.46 |
| CHEMBL146104 | — | — | 1 | 7.31 |
| CHEMBL148141 | — | — | 1 | 7.30 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.24 |
| CHEMBL174108 | — | — | 1 | 7.21 |
| CHEMBL41290 | — | — | 1 | 7.17 |
| CHEMBL356939 | — | — | 1 | 6.82 |
| CHEMBL148263 | — | — | 1 | 6.65 |
| CHEMBL147556 | — | — | 1 | 6.31 |
| CHEMBL177706 | — | — | 1 | 6.22 |
| CHEMBL175042 | — | — | 1 | 6.14 |
| CHEMBL148027 | — | — | 1 | 5.75 |
| CHEMBL177707 | — | — | 1 | 5.70 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.66 |
| CHEMBL178168 | — | — | 1 | 5.61 |
| CHEMBL178220 | — | — | 1 | 5.22 |
| CHEMBL146315 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL145869 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL174780 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL145826 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL147597 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL146101 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL173888 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL179290 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL146104 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL148141 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL174108 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL41290 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL356939 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL148263 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL147556 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL177706 | — | IC50 | = | 608.0 | nM | 6.22 |
| CHEMBL175042 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL148027 | — | IC50 | = | 1762.0 | nM | 5.75 |
| CHEMBL177707 | — | IC50 | = | 2002.0 | nM | 5.70 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL178168 | — | IC50 | = | 2433.0 | nM | 5.61 |
| CHEMBL178220 | — | IC50 | = | 6075.0 | nM | 5.22 |
| CHEMBL146315 | — | IC50 | = | 9485.0 | nM | 5.02 |