Assay Detail
Binding
CHEMBL872738
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity at 1 uM concentration against N-methyl-D-aspartate glutamate receptor, using [3H]CGP-39653 binding assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.76 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12513 | — | — | 1 | 9.10 |
| CHEMBL12804 | — | — | 1 | 9.00 |
| CHEMBL12242 | — | — | 1 | 8.92 |
| CHEMBL537478 | — | — | 1 | 8.82 |
| CHEMBL273662 | — | — | 1 | 8.82 |
| CHEMBL274422 | — | — | 1 | 8.82 |
| CHEMBL269683 | — | — | 1 | 8.77 |
| CHEMBL536107 | — | — | 1 | 8.70 |
| CHEMBL552664 | — | — | 1 | 8.52 |
| CHEMBL557993 | — | — | 1 | 8.39 |
| CHEMBL12256 | — | — | 1 | 8.13 |
| CHEMBL273636 | — | — | 1 | 8.10 |
| CHEMBL275906 | — | — | 1 | 8.09 |
| CHEMBL268920 | — | — | 1 | 8.01 |
| CHEMBL275966 | — | — | 1 | 7.77 |
| CHEMBL12414 | — | — | 1 | 7.57 |
| CHEMBL273686 | — | — | 1 | 7.51 |
| CHEMBL276670 | — | — | 1 | 7.42 |
| CHEMBL543722 | — | — | 1 | 7.40 |
| CHEMBL543489 | — | — | 1 | 7.22 |
| CHEMBL543252 | — | — | 1 | 7.19 |
| CHEMBL536106 | — | — | 1 | 7.10 |
| CHEMBL12301 | — | — | 1 | 6.92 |
| CHEMBL12546 | — | — | 1 | 6.89 |
| CHEMBL12733 | — | — | 1 | 6.80 |
| CHEMBL12706 | — | — | 1 | 6.60 |
| CHEMBL268714 | — | — | 1 | 6.43 |
| CHEMBL273889 | — | — | 1 | 6.07 |
| CHEMBL12728 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12513 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL12804 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL12242 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL537478 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL273662 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL274422 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL269683 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL536107 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL552664 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL557993 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL12256 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL273636 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL275906 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL268920 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL275966 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL12414 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL273686 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL276670 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL543722 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL543489 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL543252 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL536106 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL12301 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL12546 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL12733 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL12706 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL268714 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL273889 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL12728 | — | IC50 | = | 1100.0 | nM | 5.96 |