Assay Detail
Binding
CHEMBL872782
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Binding affinity against human Dopamine receptor D4 in CHO-K1 cells using [3H]spiperone as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.61 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431367 | ROXINDOLE | 2.0 | 1 | 7.62 |
| CHEMBL108531 | — | — | 1 | 6.64 |
| CHEMBL109063 | — | — | 1 | 6.56 |
| CHEMBL109101 | — | — | 1 | 6.43 |
| CHEMBL110489 | — | — | 1 | 6.24 |
| CHEMBL108463 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431367 | ROXINDOLE | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL108531 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL109063 | — | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL109101 | — | Ki | = | 371.0 | nM | 6.43 |
| CHEMBL110489 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL108463 | — | Ki | = | 681.0 | nM | 6.17 |