Assay Detail
Functional
CHEMBL872788
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Antagonistic activity against metabotropic glutamate receptor 4 (mGluR4) was evaluated
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.75 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97200 | — | — | 1 | 5.06 |
| CHEMBL329920 | — | — | 1 | 5.03 |
| CHEMBL95868 | — | — | 1 | 5.00 |
| CHEMBL319279 | — | — | 1 | 4.94 |
| CHEMBL319732 | — | — | 1 | 4.90 |
| CHEMBL420262 | — | — | 1 | 4.70 |
| CHEMBL432038 | — | — | 1 | 4.66 |
| CHEMBL439775 | — | — | 1 | 4.22 |
| CHEMBL97574 | — | — | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97200 | — | IC50 | = | 8680.0 | nM | 5.06 |
| CHEMBL329920 | — | IC50 | = | 9450.0 | nM | 5.03 |
| CHEMBL95868 | — | IC50 | = | 10080.0 | nM | 5.00 |
| CHEMBL319279 | — | IC50 | = | 11410.0 | nM | 4.94 |
| CHEMBL319732 | — | IC50 | = | 12530.0 | nM | 4.90 |
| CHEMBL420262 | — | IC50 | = | 20120.0 | nM | 4.70 |
| CHEMBL432038 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL439775 | — | IC50 | = | 60350.0 | nM | 4.22 |
| CHEMBL97574 | — | IC50 | = | 62850.0 | nM | 4.20 |