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Assay Detail

CHEMBL872823

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Binding
Inhibition of calmodulin-dependent Phosphodiesterase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Rationally designed analogues of tamoxifen with improved calmodulin antagonism.
Hardcastle IR, Rowlands MG, Houghton J, Parr IB, Potter GA, Jarman M, Edwards KJ, Laughton CA, Trent JO, Neidle S.
J Med Chem (1995) 38 : 241 -248
PubMed 7830266 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.63 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267035 1 6.00
CHEMBL269472 1 5.96
CHEMBL267426 1 5.89
CHEMBL266086 1 5.85
CHEMBL6318 IDOXIFENE 2.0 1 5.82
CHEMBL81418 1 5.75
CHEMBL6730 1 5.64
CHEMBL415470 1 5.48
CHEMBL309503 1 5.43
CHEMBL315041 1 5.34
CHEMBL2137046 1 4.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267035 IC50 = 1000.0 nM 6.00
CHEMBL269472 IC50 = 1100.0 nM 5.96
CHEMBL267426 IC50 = 1300.0 nM 5.89
CHEMBL266086 IC50 = 1400.0 nM 5.85
CHEMBL6318 IDOXIFENE IC50 = 1500.0 nM 5.82
CHEMBL81418 IC50 = 1800.0 nM 5.75
CHEMBL6730 IC50 = 2300.0 nM 5.64
CHEMBL415470 IC50 = 3300.0 nM 5.48
CHEMBL309503 IC50 = 3700.0 nM 5.43
CHEMBL315041 IC50 = 4600.0 nM 5.34
CHEMBL2137046 IC50 = 19000.0 nM 4.72