Assay Detail
Binding
CHEMBL872882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human Dopamine receptor D2 was determined via standard competitive displacement assay using [3H]-YM 09151 as radioligand
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 6.01 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104160 | — | — | 1 | 7.46 |
| CHEMBL317879 | — | — | 1 | 6.93 |
| CHEMBL326670 | — | — | 1 | 6.92 |
| CHEMBL326250 | — | — | 1 | 6.89 |
| CHEMBL319927 | — | — | 1 | 6.74 |
| CHEMBL441274 | — | — | 1 | 6.73 |
| CHEMBL106916 | — | — | 1 | 6.68 |
| CHEMBL106742 | — | — | 1 | 6.51 |
| CHEMBL104713 | — | — | 1 | 6.47 |
| CHEMBL323213 | — | — | 1 | 6.42 |
| CHEMBL105625 | — | — | 1 | 6.35 |
| CHEMBL319650 | — | — | 1 | 6.31 |
| CHEMBL107793 | — | — | 1 | 6.29 |
| CHEMBL69584 | — | — | 1 | 6.16 |
| CHEMBL107384 | — | — | 1 | 6.05 |
| CHEMBL106998 | — | — | 1 | 5.77 |
| CHEMBL107338 | — | — | 1 | 5.71 |
| CHEMBL106598 | — | — | 1 | 5.67 |
| CHEMBL107391 | — | — | 1 | 5.65 |
| CHEMBL321871 | — | — | 1 | 5.60 |
| CHEMBL317266 | — | — | 1 | 5.59 |
| CHEMBL323537 | — | — | 1 | 5.58 |
| CHEMBL104196 | — | — | 1 | 5.58 |
| CHEMBL107962 | — | — | 1 | 5.48 |
| CHEMBL321058 | — | — | 1 | 5.46 |
| CHEMBL106917 | — | — | 1 | 5.42 |
| CHEMBL318760 | — | — | 1 | 5.42 |
| CHEMBL106897 | — | — | 1 | 5.38 |
| CHEMBL320067 | — | — | 1 | 5.36 |
| CHEMBL107229 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104160 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL317879 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL326670 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL326250 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL319927 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL441274 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL106916 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL106742 | — | Ki | = | 306.0 | nM | 6.51 |
| CHEMBL104713 | — | Ki | = | 341.0 | nM | 6.47 |
| CHEMBL323213 | — | Ki | = | 377.0 | nM | 6.42 |
| CHEMBL105625 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL319650 | — | Ki | = | 487.0 | nM | 6.31 |
| CHEMBL107793 | — | Ki | = | 509.0 | nM | 6.29 |
| CHEMBL69584 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL107384 | — | Ki | = | 883.0 | nM | 6.05 |
| CHEMBL106998 | — | Ki | = | 1692.0 | nM | 5.77 |
| CHEMBL107338 | — | Ki | = | 1926.0 | nM | 5.71 |
| CHEMBL106598 | — | Ki | = | 2145.0 | nM | 5.67 |
| CHEMBL107391 | — | Ki | = | 2220.0 | nM | 5.65 |
| CHEMBL321871 | — | Ki | = | 2524.0 | nM | 5.60 |
| CHEMBL317266 | — | Ki | = | 2552.0 | nM | 5.59 |
| CHEMBL323537 | — | Ki | = | 2629.0 | nM | 5.58 |
| CHEMBL104196 | — | Ki | = | 2610.0 | nM | 5.58 |
| CHEMBL107962 | — | Ki | = | 3325.0 | nM | 5.48 |
| CHEMBL321058 | — | Ki | = | 3431.0 | nM | 5.46 |
| CHEMBL106917 | — | Ki | = | 3780.0 | nM | 5.42 |
| CHEMBL318760 | — | Ki | = | 3780.0 | nM | 5.42 |
| CHEMBL106897 | — | Ki | = | 4126.0 | nM | 5.38 |
| CHEMBL320067 | — | Ki | = | 4375.0 | nM | 5.36 |
| CHEMBL107229 | — | Ki | = | 4623.0 | nM | 5.33 |
| CHEMBL107755 | — | Ki | = | 5847.0 | nM | 5.23 |
| CHEMBL105595 | — | Ki | = | 6357.0 | nM | 5.20 |
| CHEMBL104251 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL104432 | — | Ki | > | 1000.0 | nM | - |