Assay Detail
Binding
CHEMBL872891
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Binding affinity towards human dopamine D2 receptor, using [3H]YM-09151 as a radioligand
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 6.13 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104273 | — | — | 1 | 7.64 |
| CHEMBL104716 | — | — | 1 | 7.41 |
| CHEMBL104719 | — | — | 1 | 7.28 |
| CHEMBL104832 | — | — | 1 | 7.21 |
| CHEMBL419356 | — | — | 1 | 7.15 |
| CHEMBL104788 | — | — | 1 | 7.04 |
| CHEMBL105304 | — | — | 1 | 6.92 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.86 |
| CHEMBL104579 | — | — | 1 | 6.80 |
| CHEMBL105011 | — | — | 1 | 6.78 |
| CHEMBL107742 | — | — | 1 | 6.73 |
| CHEMBL107020 | — | — | 1 | 6.67 |
| CHEMBL321734 | — | — | 1 | 6.65 |
| CHEMBL326202 | — | — | 1 | 6.29 |
| CHEMBL419908 | — | — | 1 | 6.21 |
| CHEMBL321538 | — | — | 1 | 6.12 |
| CHEMBL106914 | — | — | 1 | 6.08 |
| CHEMBL104614 | — | — | 1 | 6.05 |
| CHEMBL104380 | — | — | 1 | 6.01 |
| CHEMBL108157 | — | — | 1 | 5.92 |
| CHEMBL322567 | — | — | 1 | 5.91 |
| CHEMBL106751 | — | — | 1 | 5.90 |
| CHEMBL104155 | — | — | 1 | 5.85 |
| CHEMBL104256 | — | — | 1 | 5.82 |
| CHEMBL322326 | — | — | 1 | 5.79 |
| CHEMBL320440 | — | — | 1 | 5.75 |
| CHEMBL419916 | — | — | 1 | 5.72 |
| CHEMBL323525 | — | — | 1 | 5.68 |
| CHEMBL107804 | — | — | 1 | 5.52 |
| CHEMBL106208 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104273 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL104716 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL104719 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL104832 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL419356 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL104788 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL105304 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL42 | CLOZAPINE | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL104579 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL105011 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL107742 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL107020 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL321734 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL326202 | — | Ki | = | 518.0 | nM | 6.29 |
| CHEMBL419908 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL321538 | — | Ki | = | 753.0 | nM | 6.12 |
| CHEMBL106914 | — | Ki | = | 834.0 | nM | 6.08 |
| CHEMBL104614 | — | Ki | = | 887.0 | nM | 6.05 |
| CHEMBL104380 | — | Ki | = | 979.0 | nM | 6.01 |
| CHEMBL108157 | — | Ki | = | 1207.0 | nM | 5.92 |
| CHEMBL322567 | — | Ki | = | 1225.0 | nM | 5.91 |
| CHEMBL106751 | — | Ki | = | 1252.0 | nM | 5.90 |
| CHEMBL104155 | — | Ki | = | 1414.0 | nM | 5.85 |
| CHEMBL104256 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL322326 | — | Ki | = | 1642.0 | nM | 5.79 |
| CHEMBL320440 | — | Ki | = | 1784.0 | nM | 5.75 |
| CHEMBL419916 | — | Ki | = | 1918.0 | nM | 5.72 |
| CHEMBL323525 | — | Ki | = | 2094.0 | nM | 5.68 |
| CHEMBL107804 | — | Ki | = | 3011.0 | nM | 5.52 |
| CHEMBL106208 | — | Ki | = | 3823.0 | nM | 5.42 |
| CHEMBL104138 | — | Ki | = | 4742.0 | nM | 5.32 |
| CHEMBL323022 | — | Ki | = | 5247.0 | nM | 5.28 |
| CHEMBL104321 | — | Ki | = | 5287.0 | nM | 5.28 |
| CHEMBL104498 | — | Ki | = | 5847.0 | nM | 5.23 |
| CHEMBL104399 | — | Ki | = | 5839.0 | nM | 5.23 |
| CHEMBL107351 | — | Ki | = | 6740.0 | nM | 5.17 |
| CHEMBL104063 | — | Ki | = | 8053.0 | nM | 5.09 |
| CHEMBL104756 | — | Ki | = | 8620.0 | nM | 5.06 |
| CHEMBL104800 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL106007 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL104497 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL104514 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL104238 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL419911 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL108261 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL324867 | — | Ki | > | 7000.0 | nM | - |
| CHEMBL106067 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL104299 | — | Ki | > | 1000.0 | nM | - |