Assay Detail
Binding
CHEMBL872893
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In vitro binding affinity at human Dopamine receptor D3 expressed in CHO K1 cells was measured by its ability to displace [3H]spiperone
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Further characterization of structural requirements for ligands at the dopamine D(2) and D(3) receptor: exploring the thiophene moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.48 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102582 | — | — | 1 | 9.68 |
| CHEMBL15136 | — | — | 1 | 9.27 |
| CHEMBL301559 | — | — | 1 | 9.24 |
| CHEMBL1303 | ROTIGOTINE | 4.0 | 1 | 8.40 |
| CHEMBL322638 | — | — | 1 | 7.92 |
| CHEMBL103857 | — | — | 1 | 7.55 |
| CHEMBL103622 | — | — | 1 | 7.40 |
| CHEMBL103912 | — | — | 1 | 7.22 |
| CHEMBL102414 | — | — | 1 | 7.08 |
| CHEMBL105623 | — | — | 1 | 6.97 |
| CHEMBL103441 | — | — | 1 | 6.93 |
| CHEMBL102632 | — | — | 1 | 6.62 |
| CHEMBL104135 | — | — | 1 | 6.61 |
| CHEMBL316584 | — | — | 1 | 5.80 |
| CHEMBL319051 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102582 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL15136 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL301559 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL1303 | ROTIGOTINE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL322638 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL103857 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL103622 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL103912 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL102414 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL105623 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL103441 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL102632 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL104135 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL316584 | — | Ki | = | 1566.0 | nM | 5.80 |
| CHEMBL319051 | — | Ki | = | 3000.0 | nM | 5.52 |