Assay Detail
Binding
CHEMBL872918
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Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat cortical membrane homogenates
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.49 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277120 | — | — | 1 | 7.75 |
| CHEMBL278509 | — | — | 1 | 7.16 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 6.64 |
| CHEMBL80691 | — | — | 1 | 6.51 |
| CHEMBL80775 | — | — | 1 | 5.92 |
| CHEMBL9434 | PHENYLPIPERAZINE | — | 1 | 5.68 |
| CHEMBL30294 | — | — | 1 | 4.96 |
| CHEMBL77072 | — | — | 1 | 4.46 |
| CHEMBL78878 | — | — | 1 | 4.30 |
| CHEMBL80988 | — | — | 1 | 4.30 |
| CHEMBL75983 | — | — | 1 | 4.15 |
| CHEMBL61236 | — | — | 1 | 4.10 |
| CHEMBL76495 | — | — | 1 | - |
| CHEMBL80298 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277120 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL278509 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL80691 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL80775 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL9434 | PHENYLPIPERAZINE | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL30294 | — | Ki | = | 11100.0 | nM | 4.96 |
| CHEMBL77072 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL78878 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL80988 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL75983 | — | Ki | = | 71000.0 | nM | 4.15 |
| CHEMBL61236 | — | Ki | = | 79000.0 | nM | 4.10 |
| CHEMBL76495 | — | Ki | > | 150000.0 | nM | - |
| CHEMBL80298 | — | Ki | > | 300000.0 | nM | - |