Assay Detail
Functional
CHEMBL872936
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In vitro inhibitory activity was evaluated on cholesterol biosynthesis in HepG2 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.75 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2220442 | FLUVASTATIN | 4.0 | 1 | 7.55 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 7.40 |
| CHEMBL1144 | PRAVASTATIN | 4.0 | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2220442 | FLUVASTATIN | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1144 | PRAVASTATIN | IC50 | = | 5100.0 | nM | 5.29 |