Assay Detail
Functional
CHEMBL872969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in non-NTR-expressing human colon carcinoma cell line (WiDr).
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.83 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288377 | — | — | 1 | 9.70 |
| CHEMBL37705 | — | — | 1 | 8.80 |
| CHEMBL314487 | — | — | 1 | 8.22 |
| CHEMBL84381 | — | — | 1 | 7.01 |
| CHEMBL313563 | — | — | 1 | 7.00 |
| CHEMBL314247 | — | — | 1 | 6.96 |
| CHEMBL314246 | — | — | 1 | 6.89 |
| CHEMBL316382 | — | — | 1 | 6.85 |
| CHEMBL311195 | — | — | 1 | 6.81 |
| CHEMBL311087 | — | — | 1 | 6.72 |
| CHEMBL79354 | — | — | 1 | 6.57 |
| CHEMBL78019 | — | — | 1 | 6.53 |
| CHEMBL83545 | — | — | 1 | 6.53 |
| CHEMBL84463 | — | — | 1 | 6.41 |
| CHEMBL311598 | — | — | 1 | 6.39 |
| CHEMBL23612 | — | — | 1 | 4.40 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288377 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL37705 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL314487 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL84381 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL313563 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL314247 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL314246 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL316382 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL311195 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL311087 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL79354 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL78019 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL83545 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL84463 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL311598 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL23612 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 54000.0 | nM | 4.27 |