Assay Detail
Binding
CHEMBL872978
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Inhibitory effect was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.
24
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | herpes simplex virus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Ribonucleoside-diphosphate reductase RR1 (CHEMBL2095215) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.39 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336289 | — | — | 1 | 9.22 |
| CHEMBL1169533 | — | — | 2 | 8.70 |
| CHEMBL133754 | — | — | 1 | 8.52 |
| CHEMBL305199 | — | — | 1 | 8.52 |
| CHEMBL335164 | — | — | 1 | 8.30 |
| CHEMBL134961 | — | — | 1 | 8.22 |
| CHEMBL37210 | — | — | 1 | 8.15 |
| CHEMBL133827 | — | — | 1 | 8.15 |
| CHEMBL71945 | — | — | 1 | 7.82 |
| CHEMBL443029 | — | — | 1 | 7.75 |
| CHEMBL1169532 | — | — | 1 | 7.70 |
| CHEMBL305229 | — | — | 1 | 7.62 |
| CHEMBL131682 | — | — | 1 | 7.57 |
| CHEMBL132130 | — | — | 1 | 7.40 |
| CHEMBL131731 | — | — | 1 | 7.00 |
| CHEMBL280440 | — | — | 1 | 6.46 |
| CHEMBL71721 | — | — | 1 | 6.36 |
| CHEMBL132309 | — | — | 1 | 6.30 |
| CHEMBL445620 | — | — | 1 | 6.07 |
| CHEMBL132477 | — | — | 1 | 5.72 |
| CHEMBL335383 | — | — | 1 | 5.70 |
| CHEMBL134884 | — | — | 1 | 5.57 |
| CHEMBL102379 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336289 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1169533 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL305199 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL133754 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL335164 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL134961 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL37210 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL133827 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL71945 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL443029 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1169532 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL305229 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL131682 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL132130 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1169533 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL131731 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL280440 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL71721 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL132309 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL445620 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL132477 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL335383 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL134884 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL102379 | — | IC50 | = | 760000.0 | nM | - |