Assay Detail
Binding
CHEMBL872980
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In vitro inhibitory activity against monkey plasma renin
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tetrahydroisoquinoline as a phenylalanine replacement in renin inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.08 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62380 | — | — | 1 | 9.80 |
| CHEMBL34894 | — | — | 1 | 9.44 |
| CHEMBL291139 | — | — | 1 | 9.38 |
| CHEMBL60610 | — | — | 1 | 8.57 |
| CHEMBL291804 | — | — | 1 | 8.54 |
| CHEMBL60892 | — | — | 1 | 8.44 |
| CHEMBL64454 | — | — | 1 | 7.94 |
| CHEMBL292309 | — | — | 1 | 7.00 |
| CHEMBL63022 | — | — | 1 | 6.84 |
| CHEMBL62930 | — | — | 1 | 6.49 |
| CHEMBL60210 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62380 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL34894 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL291139 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL60610 | — | IC50 | = | 2.71 | nM | 8.57 |
| CHEMBL291804 | — | IC50 | = | 2.89 | nM | 8.54 |
| CHEMBL60892 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL64454 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL292309 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL63022 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL62930 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL60210 | — | IC50 | = | 373.0 | nM | 6.43 |