Assay Detail
Binding
CHEMBL872985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 Reverse transcriptase using poly-(ra)-oligo(dt) as the template primer.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel modifications in the alkenyldiarylmethane (ADAM) series of non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.50 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357187 | — | — | 1 | 6.10 |
| CHEMBL107200 | — | — | 1 | 6.00 |
| CHEMBL357658 | — | — | 1 | 5.92 |
| CHEMBL294840 | — | — | 1 | 5.72 |
| CHEMBL144654 | — | — | 1 | 5.72 |
| CHEMBL144701 | — | — | 1 | 5.47 |
| CHEMBL343398 | — | — | 1 | 5.38 |
| CHEMBL144209 | — | — | 1 | 4.69 |
| CHEMBL145842 | — | — | 1 | 4.50 |
| CHEMBL343149 | — | — | 1 | - |
| CHEMBL144509 | — | — | 1 | - |
| CHEMBL142532 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357187 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL107200 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL357658 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL294840 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL144654 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL144701 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL343398 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL144209 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL145842 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL343149 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL144509 | — | IC50 | - | nM | - | |
| CHEMBL142532 | — | IC50 | > | 100000.0 | nM | - |