Assay Detail
Functional
CHEMBL872989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Retinoic acid receptor RXR-alpha antagonist was determined in vitro
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.13 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88931 | — | — | 1 | 9.00 |
| CHEMBL414218 | — | — | 1 | 8.40 |
| CHEMBL91779 | — | — | 1 | 8.40 |
| CHEMBL92430 | — | — | 1 | 8.40 |
| CHEMBL423503 | — | — | 1 | 8.22 |
| CHEMBL42314 | — | — | 1 | 8.10 |
| CHEMBL92050 | — | — | 1 | 8.10 |
| CHEMBL92487 | — | — | 1 | 8.10 |
| CHEMBL90254 | — | — | 1 | 7.89 |
| CHEMBL313647 | — | — | 1 | 7.80 |
| CHEMBL315986 | — | — | 1 | 7.77 |
| CHEMBL420249 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88931 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL414218 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL91779 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL92430 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL423503 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL42314 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL92050 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL92487 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL90254 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL313647 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL315986 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL420249 | — | IC50 | = | 43.0 | nM | 7.37 |