Assay Detail
Binding
CHEMBL872992
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Inhibitory activity against HIV-1 reverse transcriptase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.03 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436546 | — | — | 1 | 8.22 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 8.10 |
| CHEMBL31871 | HEPT | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436546 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL35033 | EMIVIRINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL31871 | HEPT | IC50 | = | 17000.0 | nM | 4.77 |