Assay Detail
Binding
CHEMBL872994
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Inhibitory activity against HIV-1 Mutant Reverse transcriptase P236L
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 7. 8-Arylethyldipyridodiazepinones as potent broad-spectrum inhibitors of wild-type and mutant enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.64 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.10 |
| CHEMBL100056 | — | — | 1 | 7.05 |
| CHEMBL102113 | — | — | 1 | 6.72 |
| CHEMBL100833 | — | — | 1 | 6.60 |
| CHEMBL321544 | — | — | 1 | 6.26 |
| CHEMBL102192 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL100056 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL102113 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL100833 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL321544 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL102192 | — | IC50 | = | 840.0 | nM | 6.08 |