Assay Detail
Binding
CHEMBL873016
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Inhibition of specific binding of [3H]LTB4 to LTB4 receptor in human neutrophils
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Diaryl ether/carboxylic acid derivatives of LY255283: Receptor antagonists of leukotriene B4
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.99 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65061 | LEUKOTRIENE_B4 | — | 1 | 8.72 |
| CHEMBL61542 | — | — | 1 | 7.62 |
| CHEMBL15766 | LY-255283 | — | 1 | 7.07 |
| CHEMBL61919 | — | — | 1 | 7.03 |
| CHEMBL61913 | — | — | 1 | 6.89 |
| CHEMBL61770 | — | — | 1 | 6.80 |
| CHEMBL303109 | — | — | 1 | 6.72 |
| CHEMBL14823 | SC-41390 | — | 1 | 6.70 |
| CHEMBL61920 | — | — | 1 | 6.54 |
| CHEMBL61063 | — | — | 1 | 6.48 |
| CHEMBL59656 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65061 | LEUKOTRIENE_B4 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL61542 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL15766 | LY-255283 | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL61919 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL61913 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL61770 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL303109 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL14823 | SC-41390 | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL61920 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL61063 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL59656 | — | IC50 | = | 460.0 | nM | 6.34 |