Assay Detail
Binding
CHEMBL873041
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In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1A
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.55 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | 4.0 | 1 | 10.52 |
| CHEMBL295741 | — | — | 1 | 9.42 |
| CHEMBL290387 | — | — | 1 | 9.16 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 9.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL295741 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL290387 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL611 | TERAZOSIN | Ki | = | 0.82 | nM | 9.09 |