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Assay Detail

CHEMBL873050

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-prazosin from Alpha-1 adrenergic receptor of bovine frontal cortex
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Tissue Frontal cortex
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
el Ahmad Y, Laurent E, Maillet P, Talab A, Teste JF, Dokhan R, Tran G, Ollivier R.
J Med Chem (1997) 40 : 952 -960
PubMed 9083484 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 6.24 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL368061 3 7.10
CHEMBL354210 2 6.82
CHEMBL177031 3 6.39
CHEMBL49 BUSPIRONE 4.0 1 5.88
CHEMBL56 8-OH-DPAT 1 5.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL368061 Ki = 80.0 nM 7.10
CHEMBL368061 Ki = 124.0 nM 6.91
CHEMBL354210 Ki = 150.0 nM 6.82
CHEMBL354210 Ki = 190.0 nM 6.72
CHEMBL177031 Ki = 410.0 nM 6.39
CHEMBL177031 Ki = 450.0 nM 6.35
CHEMBL368061 Ki = 710.0 nM 6.15
CHEMBL49 BUSPIRONE Ki = 1320.0 nM 5.88
CHEMBL177031 Ki = 8380.0 nM 5.08
CHEMBL56 8-OH-DPAT Ki = 9460.0 nM 5.02