Assay Detail
Binding
CHEMBL873051
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Inhibitory activity against calf intestinal Adenosine deaminase (ADA)
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
AMP deaminase inhibitors. 3. SAR of 3-(carboxyarylalkyl)coformycin aglycon analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 62 | 5.85 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35777 | — | — | 1 | 7.40 |
| CHEMBL290111 | — | — | 1 | 7.22 |
| CHEMBL37183 | — | — | 1 | 7.10 |
| CHEMBL290770 | — | — | 1 | 6.89 |
| CHEMBL290381 | — | — | 1 | 6.80 |
| CHEMBL290030 | — | — | 1 | 6.80 |
| CHEMBL37181 | — | — | 1 | 6.75 |
| CHEMBL35724 | — | — | 1 | 6.50 |
| CHEMBL37750 | — | — | 1 | 5.92 |
| CHEMBL37910 | — | — | 1 | 5.85 |
| CHEMBL39389 | — | — | 1 | 5.75 |
| CHEMBL287602 | — | — | 1 | 5.64 |
| CHEMBL285253 | — | — | 1 | 5.64 |
| CHEMBL431512 | — | — | 1 | 5.62 |
| CHEMBL288909 | — | — | 1 | 5.58 |
| CHEMBL289027 | — | — | 1 | 5.42 |
| CHEMBL39924 | — | — | 1 | 5.28 |
| CHEMBL37559 | — | — | 1 | 5.25 |
| CHEMBL37090 | — | — | 1 | 5.25 |
| CHEMBL39430 | — | — | 1 | 5.21 |
| CHEMBL36699 | — | — | 1 | 5.17 |
| CHEMBL38256 | — | — | 1 | 5.06 |
| CHEMBL36790 | — | — | 1 | 5.05 |
| CHEMBL288607 | — | — | 1 | 4.92 |
| CHEMBL40107 | — | — | 1 | 4.09 |
| CHEMBL35488 | — | — | 1 | - |
| CHEMBL288184 | — | — | 1 | - |
| CHEMBL37408 | — | — | 1 | - |
| CHEMBL37305 | — | — | 1 | - |
| CHEMBL37494 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35777 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL290111 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL37183 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL290770 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL290381 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL290030 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL37181 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL35724 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL37750 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL37910 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL39389 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL287602 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL285253 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL431512 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL288909 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL289027 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL39924 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL37090 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL37559 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL39430 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL36699 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL38256 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL36790 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL288607 | — | Ki | = | 11900.0 | nM | 4.92 |
| CHEMBL40107 | — | Ki | = | 81000.0 | nM | 4.09 |
| CHEMBL290157 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL37071 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL34859 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL288414 | — | Ki | = | 270300.0 | nM | - |
| CHEMBL418056 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL36385 | — | Ki | > | 3400.0 | nM | - |
| CHEMBL288157 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL430742 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL35730 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL288819 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL39694 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL287891 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL288017 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL36636 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL448777 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL38038 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL287365 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL288013 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL39456 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL36750 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL37494 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL37305 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL37408 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL288184 | — | Ki | > | 7500.0 | nM | - |
| CHEMBL35488 | — | Ki | > | 100000.0 | nM | - |