Assay Detail
Binding
CHEMBL873053
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at Mutant (H272E) human adenosine A3 receptor expressed in COS-7 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.01 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133591 | — | — | 1 | 9.72 |
| CHEMBL133566 | — | — | 1 | 8.68 |
| CHEMBL439976 | — | — | 1 | 8.64 |
| CHEMBL129903 | — | — | 1 | 8.02 |
| CHEMBL133387 | — | — | 1 | 8.00 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 7.70 |
| CHEMBL132629 | — | — | 1 | 7.50 |
| CHEMBL340998 | — | — | 1 | 7.48 |
| CHEMBL338352 | — | — | 1 | 7.12 |
| CHEMBL133809 | — | — | 1 | 6.52 |
| CHEMBL302376 | — | — | 1 | 6.37 |
| CHEMBL128929 | — | — | 1 | 5.77 |
| CHEMBL464859 | NECA | — | 1 | 5.50 |
| CHEMBL16687 | CGS-15943 | — | 1 | 5.49 |
| CHEMBL285819 | — | — | 1 | 4.94 |
| CHEMBL273094 | XANTHINE AMINE CONGENER | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133591 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL133566 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL439976 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL129903 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL133387 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 20.1 | nM | 7.70 |
| CHEMBL132629 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL340998 | — | Ki | = | 33.3 | nM | 7.48 |
| CHEMBL338352 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL133809 | — | Ki | = | 301.0 | nM | 6.52 |
| CHEMBL302376 | — | Ki | = | 425.0 | nM | 6.37 |
| CHEMBL128929 | — | Ki | = | 1690.0 | nM | 5.77 |
| CHEMBL464859 | NECA | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL16687 | CGS-15943 | Ki | = | 3260.0 | nM | 5.49 |
| CHEMBL285819 | — | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL273094 | XANTHINE AMINE CONGENER | Ki | = | 20100.0 | nM | 4.70 |