Assay Detail
Binding
CHEMBL873066
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl)-ethylaminomethyl tetralone from human cloned Alpha-1a adrenergic receptor stably expressed in Chinese Hamster Ovary (CHO) cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 10.10 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83340 | — | — | 1 | 10.19 |
| CHEMBL313990 | — | — | 1 | 10.11 |
| CHEMBL81006 | — | — | 1 | 10.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83340 | — | Ki | = | 0.064 | nM | 10.19 |
| CHEMBL313990 | — | Ki | = | 0.077 | nM | 10.11 |
| CHEMBL81006 | — | Ki | = | 0.099 | nM | 10.00 |