Assay Detail
Functional
CHEMBL873093
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Inhibition of cell growth of murine L-1210 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chemical synthesis and biological activities of 5-deazaaminopterin analogues bearing substituent(s) at the 5- and/or 7-position(s).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.78 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428862 | — | — | 1 | 9.96 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.35 |
| CHEMBL275309 | — | — | 1 | 7.70 |
| CHEMBL432073 | — | — | 1 | 7.10 |
| CHEMBL283138 | — | — | 1 | 6.90 |
| CHEMBL19914 | — | — | 1 | 4.77 |
| CHEMBL20423 | — | — | 1 | 4.72 |
| CHEMBL19609 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428862 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL275309 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL432073 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL283138 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL19914 | — | IC50 | = | 16940.0 | nM | 4.77 |
| CHEMBL20423 | — | IC50 | = | 18880.0 | nM | 4.72 |
| CHEMBL19609 | — | IC50 | = | 18880.0 | nM | 4.72 |