Assay Detail
Binding
CHEMBL873101
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Inhibitory effect on 3'-processing(3'-P) of proximal DNA in an extracellular HIV-1 integrase assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.47 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108511 | — | — | 1 | 5.11 |
| CHEMBL611459 | 2-Hydroxy-4-oxo-4-ferrosinyl-but-2-enoic acid | — | 1 | 4.94 |
| CHEMBL35109 | — | — | 1 | 4.46 |
| CHEMBL3348567 | — | — | 1 | 4.40 |
| CHEMBL108760 | — | — | 1 | 4.19 |
| CHEMBL3348566 | — | — | 1 | 4.10 |
| CHEMBL432793 | — | — | 1 | 4.09 |
| CHEMBL108240 | — | — | 1 | - |
| CHEMBL324018 | — | — | 1 | - |
| CHEMBL432788 | — | — | 1 | - |
| CHEMBL3348565 | — | — | 1 | - |
| CHEMBL322472 | — | — | 1 | - |
| CHEMBL108150 | — | — | 1 | - |
| CHEMBL108423 | — | — | 1 | - |
| CHEMBL111081 | — | — | 1 | - |
| CHEMBL16326 | — | — | 1 | - |
| CHEMBL107490 | — | — | 1 | - |
| CHEMBL323204 | — | — | 1 | - |
| CHEMBL320261 | — | — | 1 | - |
| CHEMBL22197 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108511 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL611459 | 2-Hydroxy-4-oxo-4-ferrosinyl-but-2-enoic acid | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL35109 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3348567 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL108760 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3348566 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL432793 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL108240 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL324018 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL432788 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3348565 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL322472 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL108150 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL108423 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL111081 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL16326 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL107490 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL323204 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL320261 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL22197 | — | IC50 | > | 100000.0 | nM | - |