Assay Detail
Binding
CHEMBL873202
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Binding affinity against rat brain Cannabinoid receptor 1 using [3H]CP-55940
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.35 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476325 | — | — | 1 | 9.49 |
| CHEMBL108868 | — | — | 1 | 9.35 |
| CHEMBL108085 | — | — | 1 | 9.28 |
| CHEMBL411626 | — | — | 1 | 9.08 |
| CHEMBL108392 | — | — | 1 | 8.74 |
| CHEMBL67464 | — | — | 1 | 7.66 |
| CHEMBL325135 | — | — | 1 | 7.49 |
| CHEMBL322112 | — | — | 1 | 7.25 |
| CHEMBL111345 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476325 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL108868 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL108085 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL411626 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL108392 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL67464 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL325135 | — | Ki | = | 32.3 | nM | 7.49 |
| CHEMBL322112 | — | Ki | = | 56.9 | nM | 7.25 |
| CHEMBL111345 | — | Ki | = | 168.0 | nM | 6.78 |