Assay Detail
Binding
CHEMBL873205
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Inhibition of recombinant human 5-alpha reductase-2 at a concentration of 5 microL after pre-incubation for 10 minutes
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 9.20 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138173 | — | — | 1 | 10.40 |
| CHEMBL137733 | — | — | 1 | 10.15 |
| CHEMBL420020 | — | — | 1 | 10.10 |
| CHEMBL24088 | — | — | 1 | 10.05 |
| CHEMBL308258 | — | — | 1 | 10.05 |
| CHEMBL412425 | — | — | 1 | 9.92 |
| CHEMBL436215 | — | — | 1 | 9.89 |
| CHEMBL306722 | — | — | 1 | 9.80 |
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 9.74 |
| CHEMBL312531 | — | — | 1 | 9.64 |
| CHEMBL137691 | — | — | 1 | 9.44 |
| CHEMBL77328 | — | — | 1 | 9.40 |
| CHEMBL135780 | — | — | 1 | 9.24 |
| CHEMBL76192 | — | — | 1 | 9.06 |
| CHEMBL73816 | — | — | 1 | 8.89 |
| CHEMBL76648 | — | — | 1 | 8.82 |
| CHEMBL307626 | — | — | 1 | 8.62 |
| CHEMBL136863 | — | — | 1 | 8.55 |
| CHEMBL297524 | — | — | 1 | 8.49 |
| CHEMBL135313 | — | — | 1 | 8.17 |
| CHEMBL24291 | — | — | 1 | 8.15 |
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | 7.52 |
| CHEMBL310710 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138173 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL137733 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL420020 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL24088 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL308258 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL412425 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL436215 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL306722 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL710 | FINASTERIDE | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL312531 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL137691 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL77328 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL135780 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL76192 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL73816 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL76648 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL307626 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL136863 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL297524 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL135313 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL24291 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL138225 | EPRISTERIDE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL310710 | — | IC50 | = | 33.0 | nM | 7.48 |