Assay Detail
Binding
CHEMBL873207
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Inhibition of 3'- processing activity of HIV-1 integrase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.01 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319488 | DIDEMETHYLCURCUMIN | — | 1 | 5.22 |
| CHEMBL324842 | ROSMARINIC ACID | — | 1 | 5.05 |
| CHEMBL103410 | — | — | 1 | 4.75 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | — | 1 | - |
| CHEMBL103006 | — | — | 1 | - |
| CHEMBL179512 | DEMETHOXYCURCUMIN | — | 1 | - |
| CHEMBL102914 | — | — | 1 | - |
| CHEMBL318743 | TETRAHYDROCURCUMIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319488 | DIDEMETHYLCURCUMIN | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL324842 | ROSMARINIC ACID | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL103410 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL140 | CURCUMIN | IC50 | = | 150000.0 | nM | - |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | IC50 | = | 120000.0 | nM | - |
| CHEMBL103006 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL179512 | DEMETHOXYCURCUMIN | IC50 | = | 140000.0 | nM | - |
| CHEMBL102914 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL318743 | TETRAHYDROCURCUMIN | IC50 | > | 300000.0 | nM | - |