Assay Detail
Functional
CHEMBL873214
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit 50% growth of L1210 /1565 mutant mouse leukemia cell line was determined
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 (1565) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.17 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104230 | — | — | 1 | 6.22 |
| CHEMBL420280 | — | — | 1 | 5.92 |
| CHEMBL169981 | — | — | 1 | 5.66 |
| CHEMBL389051 | — | — | 1 | 5.44 |
| CHEMBL103059 | — | — | 1 | 5.39 |
| CHEMBL434209 | — | — | 1 | 5.08 |
| CHEMBL321977 | — | — | 1 | 4.68 |
| CHEMBL104410 | — | — | 1 | 4.09 |
| CHEMBL105026 | — | — | 1 | 4.05 |
| CHEMBL265098 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104230 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL420280 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL169981 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL389051 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL103059 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL434209 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL321977 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL104410 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL105026 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL265098 | — | IC50 | = | 160000.0 | nM | - |