Assay Detail
Binding
CHEMBL873218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for inhibitory activity against IInositol 1,4,5-trisphosphate receptor in SH-SY5Y cell line
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | SH-SY5Y |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Inositol 1,4,5-trisphosphate receptor (CHEMBL2111451) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis, calcium mobilizing, and physicochemical properties of D-chiro-inositol 1,3,4,6-tetrakisphosphate, a novel and potent ligand at the D-myo-inositol 1,4,5-trisphosphate receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.35 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 8.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279107 | INS(1,4,5)P3 | IC50 | = | 4.43 | nM | 8.35 |