Assay Detail
Binding
CHEMBL873229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against recombinant plasmid rat brain IP3K by overexpressing in Escherichia coli
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Inositol-trisphosphate 3-kinase A (CHEMBL3261) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.67 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279107 | INS(1,4,5)P3 | — | 3 | 5.58 |
| CHEMBL23552 | — | — | 1 | 4.56 |
| CHEMBL3349689 | — | — | 1 | 4.56 |
| CHEMBL3349691 | — | — | 1 | 4.41 |
| CHEMBL3349692 | — | — | 1 | 4.05 |
| CHEMBL3351092 | — | — | 1 | - |
| CHEMBL3349690 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279107 | INS(1,4,5)P3 | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL279107 | INS(1,4,5)P3 | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL23552 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL3349689 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL3349691 | — | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL279107 | INS(1,4,5)P3 | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL3349692 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL3351092 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3349690 | — | IC50 | > | 100000.0 | nM | - |