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Assay Detail

CHEMBL873239

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of SW480 (human colon cancer) cell proliferation.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SW480
Confidence 1 — Organism
Curated By Expert

Target

SW480 (CHEMBL612544)
Type CELL-LINE
Organism Homo sapiens

Publication

A new series of potent oxindole inhibitors of CDK2.
Luk KC, Simcox ME, Schutt A, Rowan K, Thompson T, Chen Y, Kammlott U, DePinto W, Dunten P, Dermatakis A.
Bioorg Med Chem Lett (2004) 14 : 913 -917
PubMed 15012993 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.73 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL355631 1 7.40
CHEMBL170130 1 7.36
CHEMBL170752 1 7.10
CHEMBL353182 1 7.05
CHEMBL536029 1 7.04
CHEMBL422738 1 7.00
CHEMBL172640 1 6.96
CHEMBL169591 1 6.89
CHEMBL354634 1 6.85
CHEMBL171297 1 6.85
CHEMBL354995 1 6.82
CHEMBL171439 1 6.69
CHEMBL366440 1 6.68
CHEMBL424207 1 6.57
CHEMBL412267 1 6.54
CHEMBL354650 1 6.40
CHEMBL352984 1 6.26
CHEMBL173058 1 6.25
CHEMBL367232 1 6.01
CHEMBL170870 1 5.93

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL355631 IC50 = 40.0 nM 7.40
CHEMBL170130 IC50 = 44.0 nM 7.36
CHEMBL170752 IC50 = 80.0 nM 7.10
CHEMBL353182 IC50 = 90.0 nM 7.05
CHEMBL536029 IC50 = 92.0 nM 7.04
CHEMBL422738 IC50 = 100.0 nM 7.00
CHEMBL172640 IC50 = 110.0 nM 6.96
CHEMBL169591 IC50 = 130.0 nM 6.89
CHEMBL354634 IC50 = 140.0 nM 6.85
CHEMBL171297 IC50 = 140.0 nM 6.85
CHEMBL354995 IC50 = 150.0 nM 6.82
CHEMBL171439 IC50 = 205.0 nM 6.69
CHEMBL366440 IC50 = 210.0 nM 6.68
CHEMBL424207 IC50 = 270.0 nM 6.57
CHEMBL412267 IC50 = 290.0 nM 6.54
CHEMBL354650 IC50 = 400.0 nM 6.40
CHEMBL352984 IC50 = 549.0 nM 6.26
CHEMBL173058 IC50 = 566.0 nM 6.25
CHEMBL367232 IC50 = 967.0 nM 6.01
CHEMBL170870 IC50 = 1185.0 nM 5.93