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Assay Detail

CHEMBL873252

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Binding
Inhibition of Selectin P binding
14
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

P-selectin (CHEMBL5378)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Studies on selectin blockers. 7. Structure-activity relationships of sialyl Lewis X mimetics based on modified Ser-Glu dipeptides.
Tsukida T, Moriyama H, Kurokawa K, Achiha T, Inoue Y, Kondo H.
J Med Chem (1998) 41 : 4279 -4287
PubMed 9784103 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.81 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3351094 1 6.52
CHEMBL3351095 1 6.52
CHEMBL3351093 1 6.52
CHEMBL2303665 3 6.42
CHEMBL2303755 1 6.35
CHEMBL3351089 1 6.22
CHEMBL450011 1 5.80
CHEMBL133134 1 5.44
CHEMBL335065 1 4.82
CHEMBL337229 1 4.43
CHEMBL2029056 1 4.00
CHEMBL375586 SIALYL LEWIS X 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3351094 IC50 = 300.0 nM 6.52
CHEMBL3351095 IC50 = 300.0 nM 6.52
CHEMBL3351093 IC50 = 300.0 nM 6.52
CHEMBL2303665 IC50 = 380.0 nM 6.42
CHEMBL2303665 IC50 = 420.0 nM 6.38
CHEMBL2303755 IC50 = 450.0 nM 6.35
CHEMBL3351089 IC50 = 600.0 nM 6.22
CHEMBL2303665 IC50 = 680.0 nM 6.17
CHEMBL450011 IC50 = 1600.0 nM 5.80
CHEMBL133134 IC50 = 3600.0 nM 5.44
CHEMBL335065 IC50 = 15000.0 nM 4.82
CHEMBL337229 IC50 = 37000.0 nM 4.43
CHEMBL2029056 IC50 = 100000.0 nM 4.00
CHEMBL375586 SIALYL LEWIS X IC50 > 1000000.0 nM -