Assay Detail
Binding
CHEMBL873255
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Compound was tested for its inhibitory activity against A/USSR/90/77 (N1) sialidases.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.91 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.70 |
| CHEMBL300461 | — | — | 1 | 7.58 |
| CHEMBL295490 | — | — | 1 | 7.52 |
| CHEMBL317645 | — | — | 1 | 7.07 |
| CHEMBL163966 | — | — | 1 | 6.92 |
| CHEMBL50254 | — | — | 1 | 5.33 |
| CHEMBL419710 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL300461 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL295490 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL317645 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL163966 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL50254 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL419710 | — | IC50 | = | 5900.0 | nM | 5.23 |