Assay Detail
Functional
CHEMBL873264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of TEM-1, class A of beta-lactamases.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.30 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6461 | Ro-481220 | — | 1 | 5.96 |
| CHEMBL124961 | — | — | 1 | 5.92 |
| CHEMBL333078 | — | — | 1 | 5.89 |
| CHEMBL333581 | — | — | 1 | 5.25 |
| CHEMBL124227 | — | — | 1 | 5.19 |
| CHEMBL123029 | — | — | 1 | 5.04 |
| CHEMBL124960 | — | — | 1 | 5.00 |
| CHEMBL123702 | — | — | 1 | 4.92 |
| CHEMBL124507 | — | — | 1 | 4.92 |
| CHEMBL2111804 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6461 | Ro-481220 | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL124961 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL333078 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL333581 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL124227 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL123029 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL124960 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL123702 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL124507 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2111804 | — | IC50 | = | 13000.0 | nM | 4.89 |